The blue-chip index fell 1.1%, with miners declining 2.7% on lower metal prices. Oil majors BP and Royal Dutch Shell slipped 1.8% each, tracking crude prices.
The domestically focussed mid-cap FTSE 250 index slid 0.5%.
Official figures showed British consumer price inflation more than doubled in April to stand at 1.5%, helped by a jump in regulated electricity and gas bills and higher clothing prices.
A Reuters poll of economists had pointed to a rise in inflation to 1.4%.
Ferguson climbed 4.1% to hit a record high after the plumbing and heating parts distributor reported a 65.4% jump in its third-quarter profit.
John Laing Group jumped 11.1% after private-equity firm KKR agreed to buy the British infrastructure investor in a deal valued at about 2 billion pounds ($2.84 billion). Reporting by Devik Jain in Bengaluru; Editing by Subhranshu Sahu